From the
U.S. Center for Disease Control (CDC) -
- ...it is the most sedating medication
- ... promethazine has the greatest adverse impact on psychomotor performance, both in severity and duration of side effects….
Common -
- drowsiness,
- dry mouth/nose/throat,
- blurred vision,
- urinary retention,
- thick respiratory secretions.
Less common -
- dizziness,
- weakness,
- hypotension or hypertension,
- cardiac arrhythmia,
- wheezing,
- sweating,
- nausea,
- vomiting,
- bloating,
- diarrhea,
- constipation,
- jaundice,
- anorexia,
- headache,
- confusion,
- tinnitus,
- paradoxical hyperexcitability,
- seizures,
- psychosis,
- acute dystonic reaction,
- paresthesias,
- photosensitivity,
- anaphylaxis …
- Pronounced sedation,
- postural hypotension,
- skin rash,
- body temperature dysregulation,
- extrapyramidal symptoms,
- delirium,
- neuroleptic malignant syndrome.
|
|
In addition those listed by the CDC, the
U.S. National Institute of Health
adds the following -
- May cause breathing to slow or stop, and
- may cause death in children. …
- Listlessness
- difficulty falling asleep or staying asleep
- nightmares
- loss of coordination
- nervousness
- restlessness
- hyperactivity
- abnormally happy mood
- stuffy nose
- itching
- slowed breathing
- breathing stops for a short time
- fever
- stiff muscles
- decreased alertness
- faintness
- abnormal or uncontrollable movements
- hallucinations (seeing things or hearing voices that do not exist)
- overwhelming or unmanageable fear or emotion
- uncontrollable shaking of a part of the body
- unusual bruising or bleeding
- sore throat, fever, chills, and other signs of infection
- uncontrolled eye movements
- tongue sticking out
- abnormal neck position
- inability to respond to people around you
- hives
- swelling of the face, eyes, lips, tongue, throat, arms, hands, feet, ankles, or lower legs
- hoarseness
- difficulty breathing or swallowing
|
|
Cautions
Also caution in sulfa allergy (some formulations contain sulfite), cardiovascular disease, peptic ulcer disease.
Drug Interactions
May interact with other neurologic drugs. Epinephrine may worsen hypotension when used with antihistamine.
Comments
FDA Pregnancy category C.
- U.S. Center for Disease Control
|
|
